Abstract

• Purpose
  The purpose of this study was to examine the effects of the ulmus root-bark dressing on tissue regeneration in experimentally-induced pressure ulcers in rats.
• Method
  A randomized pretest/post-test control group time-series study design was used. Thirty-three male Sprague-Dawley rats were used in this study. The rats were anesthetized with 100mg/kg of ketamine. Pressure ulcers were induced at 140mmHg for three hours using a personally-designed pressing apparatus. For four weeks, the ulmus root-bark dressing was applied every other day in the experimental group (n=18) and a wet gauze dressing in the control group (n=15). For data analysis, the statistical program SPSS WIN 12 was used. The wounds were examined by light microscopy and electron microscopy.
• Result
  There were significant statistical differences in the size of the pressure ulcers as time went by(p=0.006). It should be noted that there were no significant statistical differences in the number of capillaries. Using light microscopy the inflammatory infiltration and neovascularization in the dermis in the experimental group emerged densely in the early stages, but recovered rapidly at the latter stages. In addition, the reepithelization of the epidermis occurred earlier than in the control group. By electron microscopy, the cell organelles of the capillary endothelial cells and the basal lamina of capillaries in the experimental group showed a more rapid maturation during the latter stages, compared with the control group.
• Conclusion
  According to this study, it can be concluded that the ulmus root-bark dressing is effective regarding the healing of pressure ulcers.
• Keywords: Pressure ulcer; Dressings; Tissue regeneration

Figure & Data

REFERENCES

Citations

Citations to this article as recorded by  

• Use of Animals for Nursing Research in Korea
  Hae Young Yoo
  Journal of Korean Biological Nursing Science.2015; 17(4): 324.     CrossRef
• The Effect of Ulmus Root-bark Dressing in Fibroblast Growth Factor and Vascular Endothelial Growth Factor of Induced Pressure Ulcer in Rats
  Yeon Kyung Na
  Journal of Korean Biological Nursing Science.2013; 15(4): 257.     CrossRef
• Factors Affecting the Healing of Pressure Ulcers in a Korean Acute Care Hospital
  Young Hee Sung, Kyung Hee Park
  Journal of Wound, Ostomy & Continence Nursing.2011; 38(1): 38.     CrossRef