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Heart Rate Variability and Metabolic Syndrome in Hospitalized Patients with Schizophrenia
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Kyunghee Lee, Jeongeon Park, Jeongim Choi, Chang Gi Park
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J Korean Acad Nurs 2011;41(6):788-794. Published online December 31, 2011
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DOI: https://doi.org/10.4040/jkan.2011.41.6.788
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 Abstract
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Purpose
Reduced heart rate variability significantly increases cardiovascular mortality. Metabolic syndrome increases the cardiac autonomic dysfunction. Recently, increasing cardiovascular mortality has been reported in patients with schizophrenia. This study was done to compare heart rate variability between adults with and without schizophrenia and to compare the relationship of heart rate variability to metabolic syndrome in hospitalized patients with schizophrenia.
Methods
This was a descriptive and correlational study in which 719 adults without schizophrenia and 308 adults with schizophrenia took part between May and June 2008. We measured the following: five-minute heart rate variability; high-frequency, low-frequency, the ratio of low-frequency to high-frequency, and the Standard Deviation of all the normal RR intervals. Data was also collected on metabolic syndrome, abdominal obesity, triglycerides, HDL cholesterol, blood pressure and fasting glucose.
Results
The Standard Deviation of all the normal RR intervals values of heart rate variability indices were 1.53±0.18. The low-frequency and high-frequency values of heart rate variability indices were significantly higher in hospitalized patients with schizophrenia (3.89±1.36; 3.80±1.20) than those in the healthy participants (2.20±0.46; 2.10±0.46). There were no significant differences between the schizophrenic patients with and without metabolic syndrome.
Conclusion
The results of this study indicate that schizophrenia patients have significantly lower cardiac autonomic control, but they have significantly higher low-frequency and high-frequency values than those of healthy adults. Use of antipsychotic drug may affect the autonomic nervous system in schizophrenic patients. Metabolic syndrome was not associated with cardiac autonomic control in schizophrenia patients.
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Citations
Citations to this article as recorded by  - Altered Heart Rate Variability During Rest in Schizophrenia: A State Marker
Anjum Datta, Sandeep Choudhary, Sunaina Soni, Rajesh Misra, Kiran Singh
Cureus.2023;[Epub] CrossRef - Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
Nicolette Stogios, Alexander Gdanski, Philip Gerretsen, Araba F. Chintoh, Ariel Graff-Guerrero, Tarek K. Rajji, Gary Remington, Margaret K. Hahn, Sri Mahavir Agarwal
npj Schizophrenia.2021;[Epub] CrossRef - Resting vagal activity in schizophrenia: Meta-analysis of heart
rate variability as a potential endophenotype
Annika Clamor, Tania M. Lincoln, Julian F. Thayer, Julian Koenig
British Journal of Psychiatry.2016; 208(1): 9. CrossRef - Factors Influencing Metabolic Syndrome among Mental Health Facility Patients with Schizophrenia
Sun-Hye Lee, Sunhee Cho
Journal of Korean Academy of Psychiatric and Mental Health Nursing.2016; 25(1): 1. CrossRef - Impact of metabolic syndrome and its components on heart rate variability during hemodialysis: a cross-sectional study
Yu-Ming Chang, Chih-Chung Shiao, Ya-Ting Huang, I-Ling Chen, Chuan-Lan Yang, Show-Chin Leu, Hung-Li Su, Jsun-Liang Kao, Shih-Ching Tsai, Rong-Na Jhen, Ching-Cherng Uen
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Julian M. Montaquila, Benjamin J. Trachik, Jeffrey S. Bedwell
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Masa Ieda, Tsuyoshi Miyaoka, Rei Wake, Kristian Liaury, Keiko Tsuchie, Michiyo Fukushima, Tomoko Araki, Satoko Ezoe, Takuji Inagaki, Jun Horiguchi
European Archives of Psychiatry and Clinical Neuroscience.2014; 264(1): 83. CrossRef - Heart rate variability and the metabolic syndrome: a systematic review of the literature
Melanie I. Stuckey, Mikko P. Tulppo, Antti M. Kiviniemi, Robert J. Petrella
Diabetes/Metabolism Research and Reviews.2014; 30(8): 784. CrossRef - Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders
Elizabeth K. Nousen, Juliana G. Franco, Elinor L. Sullivan
Neuroendocrinology.2013; 98(4): 254. CrossRef
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